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Perceptive’s Director of Engineering to present paper on leading-edge work in the pharmaceutical sector.

8 February 2018

At the forthcoming International Forum for Process and Analytical Chemistry IFPAC Annual Meeting taking place 11-14 February 2018 in North Bethesda, Maryland, USA, Perceptive’s Director of Engineering, John Mack, will be presenting a paper on leading-edge work in the pharmaceutical sector.

The topic is "Industry 4.0" and the title is "Application of Digital Design to the development of Model Predictive Control in the Pharmaceutical Industry"

An extract from the paper follows here:

"Model Predictive Control is an Advanced Process Control technique that is widely used in many process industries. It offers the ability to control a process with multiple Critical Quality Attributes (CQAs) and operational constraints. By simultaneously controlling and optimising process unit operation it is possible to automatically respond to process disturbances such as feed material variability and equipment degradation.

Traditionally, Model Predictive Controllers employ data-driven process models. The drawback of this approach is the time and material costs associated with executing the process response tests required for model development and validation. In most cases, the product generated during these tests is discarded. A more efficient approach is to employ digital design techniques to reduce the requirement for process run time during controller development. These techniques include the application of mechanistic models to provide a virtual plant for controller development.

The presentation describes several case-studies where digital design and hybrid models are used in the development or real-time execution of Model Predictive Control systems. These include applications in Crystallisation and Hot Melt Extrusion"

Co-Authors of the paper are Dr Furqan Tahir and David Lovett; Perceptive Engineering Ltd.

For more information, please contact:

Perceptive Engineering Limited
Vanguard House
Keckwick Lane
Sci-Tech Daresbury
Tel:  +44 1925 607150
Fax:  +44 1925 607161
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